Iodine-131 sodium iodide solution (for preparation of oral solution or capsules)

Approved Use: Treatment of hyperthyroidism and selected cases of thyroid carcinoma

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Brand Name: HICON®
Manufacturer: Jubilant Radiopharma
Package Insert
How Supplied: 

• 250 mCi
• 500 mCi
• 1000 mCi

Concentration: 1000 mCi/mL
Calibration:

• Sunday 12:00 ET
• Monday 12:00 ET
• Saturday 12:00 ET

Expiration:

• 9 days after calibration date (14 days after manufacture date)
• Compounded capsule expires 7 days after preparation date
• *Solution expiry versus compounded capsule expiry*

Availability: See chart below.  Earliest delivery arrives 4 days pre-cal

Ship Day	Delivery Day	Calibration Day
Monday	Tuesday	Saturday
Tuesday	Wednesday	Sunday
Wednesday	Thursday	Monday

Gelatin Capsule Blister Pack:

• Contains 10 (size #2) inner gel caps containing ~300mg dibasic sodium phosphate anhydrous USP  
• Contains 10 (size #1) empty gelatin capsules
• Discard unused capsules after all HICON® has been dispensed

NDC #: 

• 65174-880-25
• 65174-880-50
• 65174-880-00

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Kit Information
Old Formulation vs. New Formulation
​Letter from Manufacturer August 2016 (appropriate use of blister packs)
Letter from Manufacturer February 2012 (new formulation - launch date)
Letter from Manufacturer December 2011 (new formulation approved)

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Manufacturer: International Isotopes Inc.
Package Insert
How Supplied: Minimum activity 250 mCi 
Concentration: 1000 mCi/mL
Calibration: Calibrated to day of receipt

• Tuesday 12:00 MT
• Wednesday 12:00 MT
• Thursday 12:00 MT

Expiration: 14 days after production date
​Availability: Typically ships Mondays and Tuesdays

Vial Size	Min. Activity	Max. Activity	Max. Volume
1 mL	​250 mCi	750 mCi	0.75 mL
2 mL	400 mCi	1500 mCi	1.50 mL
3 mL	400 mCi	2250 mCi	2.25 mL

Gelatin Capsule Blister Pack:

• Contains 10 (size #2) inner gel caps containing ~300mg dibasic sodium phosphate anhydrous USP  
• Contains 10 (size #1) empty gelatin capsules
• 1 pack of capsules included for orders up to 750 mCi, 2 packs for orders of 750 - 1500 mCi, and 3 packs for orders of 1500 - 2250 mCi

​NDC #: 

• 1 mL V-Vial: 69208-001-15
• 2 mL V-Vial: 69208-001-25
• 3 mL V-Vial: 69208-001-35

Ordering Instructions (JAN 2019)

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​Manufacturer: Curium (DISCONTINUED 2018) 

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Clinical Guidelines:

• ATA Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer (2015)
• ATA Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer (2015)
• ​SNMMI Procedure Standard for Therapy of Thyroid Disease with Iodine-131 (Sodium Iodide) 3.0 (2012)​
• ​Radiation Safety in the Treatment of Patients with Thyroid Diseases by Radioiodine I-131: Practice Recommendations of the American Thyroid Association (2011)​
• EANM Procedure Guidelines for Therapy of Benign Thyroid Disease (2010)
• EANM Guidelines for Radioiodine Therapy of Differentiated Thyroid Cancer (2008)​

Patient Information:

• NRC: Information for Patients Administered Radioactive Iodine (I-131)​

Allergy Information:

• Radioiodine Treatment Despite History of 'Iodine Allergy'