Iodine-123 iobenguane (MIBG)

Approved Use:
  • Detection of primary or metastatic pheochromocytoma or neuroblastoma as an adjunct to other diagnostic tests
  • Scintigraphic assessment of sympathetic innervation of the myocardium by measurement of the heart to mediastinum (H/M) ratio of radioactivity uptake in patients with New York Heart Association (NYHA) class II or class III heart failure and left ventricular ejection fraction (LVEF) ≤ 35%. Among these patients, AdreView may be used to help identify patients with lower one and two year mortality risks, as indicated by an H/M ratio ≥ 1.6 
Dose: 
  • Patients ≥ 16 years of age or < 16 years of age and ≥ 70 kg: administer 10 mCi
  • Patients < 16 years of age and < 70 kg: amount scaled to the adult reference activity based on weight (see chart below)

​Brand Name: AdreView™
Manufacturer: GE Healthcare
Package Insert  
How Supplied: 10 mCi
Volume: 5 mL
Calibration: 
  • Tuesday 12:00 PT
  • Wednesday 12:00 PT
  • Thursday 12:00 PT
Expiration: 36 hours after calibration
Availability: must be ordered ≥ 2 business days in advance for delivery on calibration day
NDC #: 17156-235-01

Clinical Guidelines: 
Pediatric Dose Chart:
Weight (kg)
Dose (mCi)
3
1.0
4
1.4
6
1.9
8
2.3
10
2.7
12
3.2
14
3.6
16
4.0
18
4.4
20
4.6
22
5.0
24
5.3
26
5.6
28
5.8
30
6.2
32
6.5
34
6.8
36
7.1
38
7.3
40
7.6
42
7.8
44
8.0
46
8.2
48
8.5
50
8.8
52
9.0
54
9.0
56
9.2
58
9.2
60
9.6
62
9.6
64
9.8
66
9.8
68
9.9