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Yttrium-90 ibritumomab tiuxetan

Approved Use:
  • treatment of relapsed or refractory, low-grade or follicular B-cell non-Hodgkin's lymphoma (NHL)
  • treatment of previously untreated follicular NHL in patients who achieve a partial or complete response to first-line chemotherapy
Dose:
  • 0.4 mCi/kg for patients with normal platelet count
  • 0.3 mCi/kg in relapsed or refractory patients with platelet count 100,000 - 149,000 cells/mm^3
  • Do not treat patients with less than 100,000 platelets/mm^3
  • Maximum dose = 32 mCi

Brand Name: Zevalin®
Manufacturer: Acrotech Biopharma
Package Insert
How Supplied: Zevalin® Kit contains four vials:
  1. Zevalin® vial containing 3.2 mg ibritumomab tiuxetan in 2 mL 0.9% sodium chloride as a clear, colorless solution
  2. 50 mM sodium acetate vial containing 13.6 mg sodium acetate trihydrate in 2 mL water for injection, USP as a clear, colorless solution
  3. Formulation buffer vial containing 750 mg albumin (human), 76 mg sodium chloride, 28 mg sodium phosphate dibasic dodecahydrate, 4 mg pentetic acid, 2 mg potassium phosphate monobasic and 2 mg potassium chloride in 10 mL water for injection, pH 7.1 as a clear yellow to amber colored solution
  4. Empty reaction vial
  • Yttrium-90 chloride is shipped directly from supplier upon placement of an order for a Zevalin® cold kit.  
  • Rituximab (Rituxan®, Biogen Idec and Genentech USA) must be ordered separately.
Storage: Refrigerate
NDC #: 68152-103-03 

Product Website
Zevalin Slides (from product website)
Ordering Overview (2014)
*FDA Removes Indium-111 Bioscan Requirement* November 2011
Letter from Manufacturer May 2010 (new supplier of Y-90 chloride)

Clinical Guidelines:
ACR Practice Parameter for the Performance of Therapy with Unsealed Radiopharmaceutical Sources (2015)
Disclaimer
Created by R.C. Riberich ©2016-2025
  • Home
  • Pharmaceuticals
    • Radiopharmaceuticals >
      • C-14 urea
      • Ga-67 citrate
      • In-111 chloride
      • In-111 oxyquinoline
      • In-111 pentatate
      • In-111 pentetreotide
      • I-123 MIBG
      • I-123 ioflupane
      • I-123 sodium iodide capsules
      • I-125 HSA
      • I-125 iothalamate
      • I-131 HSA
      • I-131 sodium iodide diagnostic capsules
      • I-131 sodium iodide therapy
      • Lu-177 dotatate
      • Lu-177 vipivotide tetraxetan
      • Mo-99/Tc-99m Generator
      • Ra-223 dichloride
      • Sr-89 chloride
      • Tc-99m bicisate
      • Tc-99m carbon aerosol
      • Tc-99m exametazime
      • Tc-99m MAA
      • Tc-99m mebrofenin
      • Tc-99m medronate
      • Tc-99m mertiatide
      • Tc-99m oxidronate
      • Tc-99m pentetate
      • Tc-99m PYP
      • Tc-99m RBC
      • Tc-99m sestamibi
      • Tc-99m succimer
      • Tc-99m sulfur colloid
      • Tc-99m tetrofosmin
      • Tc-99m tilmanocept
      • Tl-201 chloride
      • Xe-133 gas
      • Y-90 chloride
      • Y-90 ibritumomab tiuxetan
    • PET Radiopharmaceuticals >
      • C-11 choline - Radio Rx
      • Cu-64 dotatate
      • F-18 florbetaben
      • F-18 florbetapir
      • F-18 flortaucipir
      • F-18 flotufolastat
      • F-18 fluciclovine
      • F-18 fludeoxyglucose
      • F-18 fluorodopa
      • F-18 fluoroestradiol
      • F-18 flurpiridaz
      • F-18 flutemetamol
      • F-18 piflufolastat
      • F-18 sodium fluoride
      • Ga-68 DOTATATE
      • Ga-68 DOTATOC
      • Ga-68 gozetotide
      • N-13 ammonia
      • Rb-82 chloride
    • Nonradioactive Adjuncts
    • Discontinued
  • Calculations
    • Unit Conversions
    • Radioactive Decay
    • Generator Elution Calcs
    • MAA Particle Calcs
    • Pediatric Dosing
  • Helpful Lists
    • Radionuclides
    • Light Sensitive Products
    • Refrigeration
    • NDC Numbers
  • Links
    • Organizations
    • Manufacturers
    • Nuclear Pharmacies
    • Universities
  • What's New
  • About
  • Contact