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Generator Elution Calculator


Tips and Instructions:
  • Time zone difference can be a negative/positive number or zero. Example: If the local time zone is Central Time and using a Lantheus TechneLite® generator (Eastern Time), time zone difference from ET would be "-1"
  • Available generator sizes can be found here:
    • GE Drytec™ *DISCONTINUED*
    • Lantheus TechneLite®
    • Curium Ultra-Technekow™ V4
  • Enter times with : separator
  • Recommended efficiency is 90-97%. Default is 93.5%.
  • "Last Elution Date" and "Last Elution Time" must be entered for each calculation. It is assumed that each generator is eluted at the manufacturing facility prior to shipping. This should be taken into account when calculating the amount of Tc-99m in-growth prior to first use. Suggested times for factory test elutions:
    • GE Drytec™ ≈ 07:00 GMT on shipping date
    • Lantheus TechneLite® Weekday-Calibrated Generator ≈ 12:00 noon ET on calibration date
    • Lantheus TechneLite® Sunday-Calibrated Generator ≈ 00:00 ET (or earlier) on calibration date
    • Curium Ultra-Technekow™ V4 ≈ 03:00 - 06:00 CT on calibration date
  • The following calculations were used:
Picture

Relationship Between Tc-99m and Mo-99 in the Generator at Various Times after Elution
Time (hr)Curies Mo-99XRatio Tc-99m:Mo-99=Curies Tc-99m
      
01.000 --- ---
0.50.995 0.048 0.048
10.990 0.094 0.093
1.50.984 0.138 0.136
20.979 0.179 0.175
2.50.974 0.218 0.212
30.969 0.255 0.247
3.50.964 0.290 0.280
40.959 0.324 0.311
4.50.954 0.356 0.340
50.949 0.386 0.366
5.50.944 0.414 0.391
60.939 0.441 0.414
6.50.934 0.467 0.436
70.929 0.492 0.457
7.50.924 0.515 0.476
80.919 0.537 0.494
8.50.915 0.558 0.511
90.910 0.578 0.526
9.50.905 0.596 0.539
100.900 0.614 0.553
10.50.895 0.631 0.565
110.891 0.647 0.576
11.50.886 0.662 0.587
120.881 0.677 0.596
130.872 0.704 0.614
140.863 0.728 0.628
150.854 0.750 0.641
160.845 0.769 0.650
170.836 0.787 0.658
180.827 0.803 0.664
190.819 0.817 0.669
200.810 0.830 0.672
210.802 0.841 0.674
220.794 0.852 0.676
*23*0.785 0.861 *0.676*
240.777 0.870 0.676
250.769 0.877 0.674
260.761 0.884 0.673
270.752 0.890 0.669
280.745 0.896 0.668
290.737 0.901 0.664
300.729 0.905 0.660
320.714 0.913 0.652
340.699 0.919 0.642
360.685 0.924 0.633
380.671 0.929 0.623
400.657 0.932 0.612
440.630 0.937 0.590
480.604 0.940 0.568
540.567 0.943 0.535
600.532 0.944 0.502
660.500 0.945 0.473
720.469 0.946 0.444
780.440 0.946 0.416
840.414 0.946 0.392
900.388 0.946 0.367
960.365 0.946 0.345
The ratio of Tc-99m to Mo-99 used in the above table was calculated using the equation:
Picture

Yield Charts Available from Manufacturers:
drytec_yield_chart.xls
File Size: 59 kb
File Type: xls
Download File

technelite_tc99m_yield_chart_mon_thru_fri.pdf
File Size: 257 kb
File Type: pdf
Download File

technelite_tc99m_yield_chart_-_sunday.pdf
File Size: 256 kb
File Type: pdf
Download File


Mo-99 Breakthrough:

Limit = 0.15 µCi Mo-99 per 1 mCi Tc-99m at time of administration.
Calculations and a chart of Tc-99m expiration times based on Mo-99 breakthrough can be found here. 
Disclaimer
Created by R.C. Riberich ©2016-2022
  • Home
  • Pharmaceuticals
    • Radiopharmaceuticals >
      • C-14 urea
      • Ga-67 citrate
      • In-111 chloride
      • In-111 oxyquinoline
      • In-111 pentatate
      • In-111 pentetreotide
      • I-123 MIBG
      • I-123 ioflupane
      • I-123 sodium iodide capsules
      • I-125 HSA
      • I-125 iothalamate
      • I-131 HSA
      • I-131 MIBG
      • I-131 sodium iodide diagnostic capsules
      • I-131 sodium iodide therapy
      • Lu-177 dotatate
      • Lu-177 vipivotide tetraxetan
      • Mo-99/Tc-99m Generator
      • Ra-223 dichloride
      • Sr-89 chloride
      • Tc-99m bicisate
      • Tc-99m exametazime
      • Tc-99m MAA
      • Tc-99m mebrofenin
      • Tc-99m medronate
      • Tc-99m mertiatide
      • Tc-99m oxidronate
      • Tc-99m pentetate
      • Tc-99m PYP
      • Tc-99m RBC
      • Tc-99m sestamibi
      • Tc-99m succimer
      • Tc-99m sulfur colloid
      • Tc-99m tetrofosmin
      • Tc-99m tilmanocept
      • Tl-201 chloride
      • Xe-133 gas
      • Y-90 chloride
      • Y-90 ibritumomab tiuxetan
    • PET Radiopharmaceuticals >
      • C-11 choline
      • Cu-64 dotatate
      • F-18 florbetaben
      • F-18 florbetapir
      • F-18 flortaucipir
      • F-18 fluciclovine
      • F-18 fludeoxyglucose
      • F-18 fluorodopa
      • F-18 fluoroestradiol
      • F-18 flutemetamol
      • F-18 piflufolastat
      • F-18 sodium fluoride
      • Ga-68 DOTATATE
      • Ga-68 DOTATOC
      • Ga-68 gozetotide
      • N-13 ammonia
      • Rb-82 chloride
    • Nonradioactive Adjuncts
    • Discontinued
  • Calculations
    • Unit Conversions
    • Radioactive Decay
    • Generator Elution Calcs
    • MAA Particle Calcs
    • Pediatric Dosing
  • Helpful Lists
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    • Light Sensitive Products
    • Refrigeration
    • NDC Numbers
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